Current practice on many NZ farms incorporates: Cattle treated with Cydectin Pour-On at the end of fly season can be re-treated during the winter without danger of grub-related reactions. In case of accidental skin contact and/or clothing contamination, wash skin thoroughly with … This article reviews the current knowledge of the use of moxidectin (MOX) in horses, including its mode of action, pharmacokinetic and pharmacodynamic properties, efficacy, safety and resistance profile. For customer service or to obtain product information, including Safety Data Sheet (SDS), call 1-800-633-3796. St. Joseph, MO 64506 U.S.A. In a pre-postnatal study in rats, parental oral administration of dietary moxidectin prior to mating, through mating, gestation, and lactation did not produce adverse effects in first-generation or secondgeneration offspring at a maternal NOAEL dose of 0.824 mg/kg/day (approximately equivalent to the recommended human dose based on body surface area comparison). The persistent activity of CYDECTIN POUR-ON FOR CATTLE & RED DEER prevents the development of viable cattle tick (Rhipicephalus (Boophilus) microplus) for 21 days after treatment. It is used for the treatment and control of gastro-intestinal worms, lungworms, liver fluke and roundworms in beef cattle. Generic Name: moxidectin liquid $88.09 $ 88. Cydectin is a registered trademark of Boehringer Ingelheim Vetmedica, Inc. A withdrawal period has not been established for this product in pre-ruminating calves. In some cases large worm burdens can develop very rapidly and cause sheep deaths without warning. The table below will assist in the calculation of the appropriate volume of drench in 1.0 mL increments and it must be administered based on the weight of animal being treated. HUMAN WARNINGS: Not for use in humans. Administer 1 mL per 11 lb (1 mL per 5 kg) body weight into the mouth of the sheep, ... HUMAN WARNINGS: Not for use in humans. Indication of immediate medical attention and special 4.6 out of 5 stars 14. … This results in paralysis and elimination of the parasite. Cydectin Pour-On has been proven to effectively control infections and protect from reinfection with Haemonchus placei for 14 days after treatment, Oesophagostomum radiatum and Ostertagia ostertagi for 28 days after treatment, and Dictyocaulus viviparus for 42 days after treatment. Source: ESR 2013 Annual Surveillance Report. Free moxidectin may adversely affect fish and certain aquatic organisms. ; RECOMMENDED FOR. Cydectin Triclamox Pour On is for the treatment of mixed trematode (fluke) and nematode (roundworm) infections and certain arthropod infestations. Keep this and all drugs out of the reach of children. 4.8 out of 5 stars 30. Cydectin Pour-On provides seven days of persistent activity against horn flies. ADMINISTRATION: CYDECTIN Oral Drench is ready-to-use. Phone: (02)9899 0444 Page 2 of 4 Issued: 4 Jul 2002 Revision 5 ll HEALTH HAZARD DATA Health Effects: No specific data is available for the product for chronic exposure symptoms. Sites for administration of CYDECTIN Injectable. Because a withholding time in milk has not been established for this product, do not use in female sheep providing milk for human consumption. Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. The effectiveness of preoperative albendazole has been studied in a randomized comparison with no treatment in 84 patients with isolated hydatid cysts of the liver. Boehringer Ingelheim Vetmedica, Inc. To obtain a copy of the material safety data sheet (MSDS) which provides more detailed occupational safety information or to report adverse reactions attributable to exposure to this product, call 1-866-638-2226. Not for use in humans. Moxidectin binds selectively and with high affinity to glutamate-gated chloride ion channels which are critical to the function of invertebrate nerve and muscle cells. There are two main types of this disease in New Zealand cattle. In horses, overdose may lead to depression , drooping of the lower lip, tremor , lack of coordination when moving ( ataxia ), decreased rate of breathing ( respiratory rate ), stupor and coma . The recommended rate of administration for CYDECTIN Oral Drench for Sheep is 1 mL per 11 lb (5 kg) body weight to provide 0.2 mg moxidectin/2.2 lb (0.2 mg/kg) body weight. CYDECTIN Injectable Solution is a ready-to-use, sterile solution containing 1% moxidectin. Exposure can take place through ingestion or topical exposure. Dosage Form: FOR ANIMAL USE ONLY. Not For Use In Humans. A protective barrier, called the blood-brain barrier, blocks ivermectin from reaching the human brain. Avoid prolonged exposure above 25°C (77°F). 4,916,154 - used under license. HUMAN WARNINGS: Not for use in humans. Cydectin Pour-On is available in three convenient package styles designed for ease of administration and the number of cattle to be treated. Figure 1. Large Conventional Container (338 fl oz/10 L Cubetainer). CYDECTIN (moxidectin) Pour-On is a ready-to-use topical formulation intended for direct application to the hair and skin in a narrow strip extending along the top of the back from the withers to the tailhead (see Figure 1). Thi… In case of ingestion do not induce vomiting and seek medical attention immediately. It has also been used off label to treat adult heartworms. If irritation or any other symptom attributable to exposure to this product persists, consult your physician. Moxidectin, also known as ProHeart®, is used primarily to prevent heartworm infection for dogs. The Select one or more newsletters to continue. It is thought to work by paralysing the parasite or inactivating the parasite gut. Moxidectin binds selectively and with high affinity to glutamate-gated chloride ion channels which are critical to the function of invertebrate nerve and muscle cells. It has been established in laboratory tests that moxidectin may temporarily affect dung beetle reproduction; however, field studies indicate no long-term effects. I use Ivomec injectable, given orally, 1ml per 50lbs. I have trialled on sacrificial roosters up to 2 ml and no ill effects. I do keep Valbazen because it is effective in killing tape worm. NADIS is a unique online based animal health resource for farmers, vets and SQPs. CYDECTIN Injectable, when administered at the recommended dose level of 0.2 mg/2.2 lb (0.2 mg/kg) body weight, is effective in the treatment and control of the following internal and external parasites of cattle: Gastrointestinal Roundworms Injection of Micotil 300 in humans has been associated with fatalities and cardiac arrest Effects of exposure may include changes in heart rate/rhythm and heart tissue changes. Moxidectin. Leptospirosis notifications and laboratory-reported cases by year, 1997 - 2013. When used according to label directions, neither a pre-slaughter drug withdrawal period nor a milk discard time are required. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Side-effects Lethargy Vomiting Diarrhea Loss of appetite Stumbling Cydectin Solution may also cause side-effects not listed here. Do not contaminate water by direct application or by improper disposal of drug containers. Due to the angular topline characteristic of most dairy breeds, it is recommended that all pour-on products be applied slowly to dairy cows. This will delouse demite and deworm your chickens effectively and safely. Moxidectin is an endectocide in the milbemycin chemical class which shares the distinctive mode of action characteristic of macrocyclic lactones. Though off label Cydectin Pouron is an accepted and widely used med for poultry and caged birds. Apply to healthy skin avoiding any mange scabs, skin lesions, mud or manure. Determine the weight of the animal, calculate the recommended volume of Cydectin Pour-On and locate the volume marker equivalent to this dose on the dosing chamber of the bottle. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. In case of accidental skin contact and/or clothing contamination, wash skin thoroughly with soap and water and launder clothing with detergent. Phone: (02)9899 0444 Page 2 of 4 Issued: 4 Jul 2002 Revision 5 ll HEALTH HAZARD DATA Health Effects: No specific data is available for the product for chronic exposure symptoms. 09. For protection against severe challenge by Haemonchus contortus (barber’s pole worm) for up to 4 months. Moxidectin binds selectively and with high affinity to glutamate-gated chloride ion channels which are critical to the function of invertebrate nerve and muscle cells. Studies indicate that when moxidectin comes in contact with the soil it readily and tightly binds to the soil and becomes inactive. PATTERSON VETERINARY Cydectin Oral Drench Wormer Sheep Internal Parasite 0.1% moxidectin 1000 ml. We can’t do it. P.J.J. To obtain a copy of the material safety data sheet (MSDS) which provides more detailed occupational safety information or to report adverse reactions attributable to exposure to this product, call 1-800-422-9874. van Genderen, in Side Effects of Drugs Annual, 2005. Cattle entering the herd following this administration should be treated prior to introduction. Moxidectin, also known as ProHeart®, is used primarily to prevent heartworm infection for dogs. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Side effects increased as the dose was raised, so there is no sense in going crazy and using a higher dose. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Efficacy below 90% was observed in some Ostertagia ostertagi persistent activity studies at 21 and 28 days posttreatment. The table below will assist in the calculation of the appropriate volume of drench in 1.0 mL increments and it must be administered based on the weight of animal being treated. Oral ivermectin appears to be a safe medication. Cydectin 2% LA Oral Drench for Sheep is a ready-to-use solution containing 0.1% Cydectin 2% LA. For Treatment and Control of Infections Due to Internal Parasites of Sheep. If ingested, increased salivation, tremors, vomiting, and decreased appetite can occur. A well-controlled U.S. study has demonstrated an adequate margin of safety to allow treatment of sheep four months of age and older with Cydectin Oral Drench. Humans lack glutamate-gated chloride channels which limits human toxicity (Cotreau et al. Figure 3. Select one or more newsletters to continue. Keep this and all drugs out of the reach of children. Moxidectin is an endectocide in the milbemycin chemical class which shares the distinctive mode of action characteristic of macrocyclic lactones. Boehringer Cydectin Pouron for Beef and Dairy Cattle. Issued by: Fort Dodge Australia Pty Limited Product: Cydectin Pour-on for Cattle and Red Deer (45970). Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Killing H. lineatum when they are located in peri-esophageal tissues may cause bloat. Cydectin Oral Drench for Sheep is a ready-to-use solution containing 0.1% moxidectin. If you have any questions, please contact your veterinarian. U.S. Patent No. Product index: CYDECTIN 10% LA Solution for Injection for Cattle Cattle - meat: 108 days Withdrawal notes: Not for use in lactating animals producing milk for human consumption or industrial purposes or within 80 days of expected parturition. Keep this and all drugs out of the reach of children. Administer 1 mL per 11 lb (1 mL per 5 kg) body weight into the mouth of the sheep, using any standard drenching equipment. Figure 1. This product can cause irritation to skin, eyes, or mucous membranes. In humans the neurotransmitters acted on by ivermectin are in the brain. In foreign countries there have been reports of adverse effects, including death. High doses that are able to cross the blood-brain barrier have a neurotoxic effect and untreated moxidectin poisoning can result in severe symptoms or death. To obtain a copy of the material safety data sheet (MSDS) which provides more detailed occupational safety information or to report adverse reactions attributable to exposure to this product, call 1-866-638-2226. Large Conventional Containers (84.54 fl oz/2.5 L and 169 fl oz/5 L Bottles), Figure 4. Moxidectin binds selectively and with high affinity to glutamate-gated chloride ion channels which are critical to the function of invertebrate nerve and muscle cells. So it appears, with a real minimum of information, that a human effective dose would be between 0.15 and 0.6 mg per kg or approximately 0.1 to 0.3 mg per pound. Cydectin is a registered trademark of Boehringer Ingelheim Vetmedica, Inc. © 2010 Boehringer Ingelheim Vetmedica, Inc. All Rights Reserved. This product should not be used in other animal species as severe adverse reactions, including fatalities in dogs, may result. Virbac’s latest addition to the Cydectin franchise, Cydectin Platinum, offers the potency and the persistency of Moxidectin as well as the broad spectrum activity of dual actives. Invert the container prior to use (2.5 L and 5 L containers only). This is a disease that is easily spread from animal to humans and is the world’s most widespread zoonosis. It would be like a human trying to live on Mars. Keep this and all drugs out of the reach of children. ... DO NOT allow material to contact humans, exposed food or food utensils. ... A long list of side effects and reactions, such as seizures, ... then 2 weeks later as I said couldn’t get up without my help. Administration Inject subcutaneously (under the skin) in the neck. In this study no signs of toxicity were seen in sheep given up to 5 times the recommended dose. Cydectin Oral Drench for Sheep has been formulated specifically for oral use in sheep and should not be given by any other route of administration. Not For Use in Humans. Cydectin Oral Drench for Sheep Indications. CYDECTIN Injectable is specially formulated to allow moxidectin to be absorbed from the site of injection and distributed internally to the areas of the body affected by endo- and/or ectoparasitism. CYDECTIN Long Acting Injection for Sheep Lambs/hoggets born in the previous spring are widely recognised as the highest risk group of sheep on New Zealand farms likely to suffer from worm effects. It is mainly found in coastal and high rainfall areas of Western Australia. In case of human injection, consult a doctor immediately and apply ice or cold pack to injection site while avoiding direct contact with the skin. These bottles are designed for use with the CYDECTIN (moxidectin) Pour-On applicators. Keep this and all drugs out of the reach of children. Not for human use. Cydectin Injectable is specially formulated to allow moxidectin to be absorbed from the site of injection and distributed internally to the areas of the body affected by endo- and/or ectoparasitism. The advice of a veterinary surgeon should be sought in using CYDECTIN 1% Solution for Injection for Sheep in a dosing programme, to ensure correct diagnosis of the nematode infection present and to minimise the risk of developing resistance. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Keep this and all drugs out of the reach of children. CYDECTIN INJECTION FOR CATTLE is effective against … Active Ingredient: Moxidectin, Triclabendazole. Keep this and all drugs out of the reach of children. Warning: Not For Use In Humans. This topical, ready-to-use formula works to control mites, lice, grubs, lungworms, and … Cydectin Pour-On is effective against the migrating stage of cattle grubs (Hypoderma larvae). H412 Harmful to aquatic life with long lasting effects. Precautionary statement(s) Prevention P273 Avoid release to the environment. Generic Name: moxidectin liquid Keep this and all drugs out of the reach of children. Cydectin Oral Drench for Sheep, when administered at the recommended dose level of 0.2 mg moxidectin/2.2 lb (0.2 mg/kg) body weight, is effective in the treatment and control of adult and larval (L4) stages of the following internal parasites of sheep: Oesophagostomum columbianum - Adult and L4, Trichostrongylus colubriformis - Adult and L4. Moxidectin, a macrocyclic lactone like ivermectin, is approved and marketed worldwide as a treatment for internal and external parasites in wide variety of companion and farm animals.It is currently under investigation in human onchocerciasis. Do not mix with any other products before administration. It is used for parasite control in horses in an oral gel formulation. Side effects increased as the dose was raised, so there is no sense in going crazy and using a higher dose. The recommended rate of administration for Cydectin Oral Drench for Sheep is 1 mL per 11 lb (5 kg) body weight to provide 0.2 mg moxidectin/2.2 lb (0.2 mg/kg) body weight. Issued by: Fort Dodge Australia Pty Limited Product: Cydectin Pour-on for Cattle and Red Deer (45970). For optimal control of horn flies, the product should be used as part of an integrated control program utilizing other methods to provide extended control. If animals are likely to be reinfected following treatment, a strategic parasite control program should be established. Not For Use in Humans. Reproductive safety studies evaluating the use of Cydectin Oral Drench in breeding ewes and rams have not been conducted in the U.S. Store product at or below 77°F (25°C). If you have any questions, please contact your veterinarian. Consult your veterinarian or a livestock entomologist for the most appropriate time to apply Cydectin Pour-On in your location to effectively control horn flies and external parasites. The table below will assist in the calculation of the appropriate volume of drench in 1.0 mL increments and it must be administered based on the weight of animal being treated. Moxidectin is an endectocide in the milbemycin chemical class which shares the distinctive mode of action characteristic of macrocyclic lactones. More patients in the moxidectin arm experienced elevation in bilirubin above the upper limit of normal and elevation in transaminases > 5x upper limit of normal. Cattle should be treated as soon as possible after heel fly (warble fly) season to avoid this potential problem. my choice of dewormers is Cydectin injectable given orally. Specific target organ toxicity, single exposure Category 3 narcotic effects Hazardous to the aquatic environment, acute Category 2 hazard ... For animal injection only. Manufactured for: Moxidectin is a drug that is used to treat parasites in dogs, cats, and large farm animals. Do not contaminate water by direct application or by improper disposal of drug containers. CYDECTIN INJECTION FOR CATTLE delivers the trusted power of moxidectin, the most trusted, potent and persistent “mectin, in a water based, non-sting formulation; CYDECTIN INJECTION FOR CATTLE provides broad spectrum control of internal and external parasites. If your parasites are resistant to cydectin, they're going to be resistant to Ivomec because it was the first product offered in its class.