Chemical and physical in-use stability for a prepared solution for bolus injection has been demonstrated upto 3 hours at controlled room temperature (15-25°C) or upto 8 hours under refrigerated conditions (2-8°C). Increased numbers of platelets in your blood (shown in a blood test). The selection of meropenem to treat an individual patient should take into account the appropriateness of using a carbapenem antibacterial agent based on factors such as severity of the infection, the prevalence of resistance to other suitable antibacterial agents and the risk of selecting for carbapenem-resistant bacteria. Swelling, redness, pain, or soreness at the injection site may occur. 30 minutes when meropenem is dissolved in glucose (dextrose). You should have your injections at the same time each day to get the most benefit and you should keep on taking this medicine for as long as you are prescribed it, even if your symptoms quickly improve. All generic drugs get approved only when their bio-equivalence is proved and not prior to that. They are for use only for organisms that do not have specific breakpoints. Merolan is also used to treat bacterial meningitis (infection of brain or spinal cord). Simultaneous administration of antibiotics with warfarin may augment its anti-coagulant effects. anaphylactic reaction, severe skin reaction) to any other type of betalactam antibacterial agent (e.g. There are limited data to support the administration of these dose adjustments for a unit dose of 2 g. (based on “unit” dose range of 500 mg or 1 g or 2 g, see table above). Acute bacterial infection of the brain (meningitis). 250 mg . Treatment of patients with bacteraemia that occurs in association with, or is suspected to be associated with, any of the infections listed above. If you get any side effects, talk to your doctor or nurse. Meropenem Powder For Injection IP 1g (Merokem) Taj Pharma, Meropenem Powder For Injection 1g Merokem Taj Pharma, Amoxicillin & Potassium Clavulanate Injection. These measures will help protect the environment. The maximum daily dose of this product is equivalent to ≥27% of the WHO recommended maximum daily intake for sodium. In preclinical models meropenem demonstrated activity when plasma concentrations exceeded the MIC of the infecting organisms for approximately 40 % of the dosing interval. Reconstituted solution of meropenem in 5% glucose (dextrose) solution should be used immediately, i.e. Meropenem is primarily excreted unchanged by the kidneys; approximately 70 % (50 –75 %) of the dose is excreted unchanged within 12 hours. urticaria, toxic epidermal necrolysis, Stevens Johnson syndrome, erythema multiforme. Buy Meropenem 500 MG Injection Online. Meropenem belongs to a group of medicines called carbapenem antibiotics. Meropenem is cleared by haemodialysis and haemofiltration. Standard aseptic techniques should be used for solution preparation and administration. Let me elucidate in a nut-shell as to why the price difference occurs in the first place. 1349.56 mg powder in a 40ml Type-I, tubular, clear glass vial with stopper (bromobutyl rubber with aluminum seals having white colour polypropylene discs). Prescribers are advised to take into account the local prevalence of resistance in these bacteria to penems. They are for use only for organisms that do not have specific breakpoints. Patients who have a history of hypersensitivity to carbapenems, penicillins or other beta-lactam antibiotics may also be hypersensitive to meropenem. Find its price or cost, dose, when to use, how to use, side effects, adverse effects, substitutes. Any unused medicinal product or waste material should be disposed of in accordance with local requirements. Comparison showed consistent pharmacokinetics between the doses and half-lives similar to those observed in adults in all but the youngest subjects (<6 months t1/2 1.6 hours). 6 The beta-lactam susceptibility of streptococcus groups A, B, C and G is inferred from the penicillin susceptibility. varies across the European Union. a) Meropenem 125mg powder for solution for injection or infusion b) Meropenem 250mg powder for solution for injection or infusion c) Meropenem 500mg powder for solution for injection or infusion d) Meropenem 1g powder for solution for injection or infusion. Meropenem is cleared by haemodialysis and haemofiltration. Hepatic function should be closely monitored during treatment with meropenem due to the risk of hepatic toxicity (hepatic dysfunction with cholestasis and cytolysis) (see section 4.8). — = Susceptibility testing not recommended as the species is a poor target for therapy with the drug. Glanders and melioidosis: Use of meropenem in humans is based on in vitro B.mallei and. How should I keep meropenem-injection stored? However, when driving or operating machines, it should be taken into account that headache, paraesthesia and convulsions have been reported for meropenem. Taj Pharma India Limited manufactures and distributes medicines. Dose adjustment of Merokem 1 gm Injection may be needed. Meropenem Powder For Injection IP 1g (Merokem) Taj Pharma Overview INTRODUCTION OF MEROKEM POWDER FOR INJECTION Merokem 1 gm Injection is an antibiotic that fights bacteria. Amikacin Sulphate Injection IP. Serious hypersensitivity reactions involving fever, skin rash, and changes in the blood tests that check how the liver is working (increased levels of liver enzymes) and an increase in a type of white blood cell (eosinophilia) and enlarged lymph nodes. DBL Meropenem for Injection contains 208 mg sodium carbonate anhydrous for each gram of meropenem (anhydrous potency). A study in patients with alcoholic cirrhosis shows no effect of liver disease on the pharmacokinetics of meropenem after repeated doses. The prevalence of acquired resistance may vary geographically and with time for selected species and local information on resistance is desirable, particularly when treating severe infections. Isolates may be reported as R without prior testing. No dose adjustment is required for the elderly with normal renal function or creatinine clearance values above 50 ml/min. This site uses cookies. This may be associated with a high fever and joint. d) Each vial contains: Meropenem Trihydrate equivalent to Meropenem             1g Excipients               q.s. Pharmacotherapeutic group: Antibacterials for systemic use, carbapenems. Swelling of the face, lips, tongue or other parts of the. Each vial of powder for solution for injection or infusion contains 1141.56 mg meropenem trihydrate equivalent to 1 g anhydrous meropenem. Chemical and physical in-use stability for a prepared solution for infusion using 0.9% sodium chloride solution has been demonstrated for 6 hours at controlled room temperature (15-25°C) or upto12 hours under refrigerated conditions (2-8°C). pH of the product after reconstitution is 7.3 to 8.3. 5 Non-species related breakpoints have been determined mainly from PK/PD data and are independent of the MIC distributions of specific species. Information about drug Meropenem includes cost of the drug and the type of drug - tablet, capsule, syrup, cream, gel, ointment, liquid or injection. If you stop taking it too early the infection may return or worsen. The pharmacokinetics of meropenem in neonates requiring anti-infective treatment showed greater clearance in neonates with higher chronological or gestational age with an overall average half-life of 2.9 hours. If not used immediately in-use storage times and conditions are the responsibility of the user. No dose adjustment is necessary in patients with hepatic impairment (see section 4.4). What Meropenem is and what it is used for, What you need to know before you take Meropenem, Contents of the pack and other information. Severe pneumonia including hospital and ventilator-associated pneumonia. In repeat dose studies of up to 6 months duration only minor effects were seen including a decrease in red cell parameters in dogs. Meropenem to be used for bolus intravenous injection should be constituted with sterile water for injection. Faecal elimination represents only approximately 2% of the dose. A solution for bolus injection is prepared by dissolving the drug product meropenem in sterile water for injection to a final concentration of 50 mg/ml. Consult your doctor if these side effects bother you or do not go away. At first generic medicines have the same amount of dosage as compared to branded medicines and the amount of content is also the same, the difference is only in size shape and taste. Effects were seen in acute toxicity studies in rodent at doses exceeding 1000 mg/kg. The company’s products include prescription solutions, lifesaving drugs, anti-cancer drugs, veterinary products, consumer brands, and CNS drugs. Meropenem is indicated for the treatment of the following infections in adults and children aged 3 months and older (see sections 4.4 and 5.1): • Severe pneumonia, including hospital and ventilator-associated pneumonia. This should be particularly taken into account for those on a low salt diet. From a microbiological point of view, unless the method of opening/reconstitution/dilution precludes the risk of microbiological contamination, the product should be used immediately. Your doctor or nurse will give you this medicine. Prescribers are advised to take into account the local prevalence of resistance in these bacteria to penems. Meropenem Injection IP 1g (Merokem) Taj Pharma. It works by killing bacteria, which can cause serious infections. A further 28% is recovered as the microbiologically inactive metabolite. Hepatic function should be closely monitored during treatment with meropenem due to the risk of hepatic toxicity (hepatic dysfunction with cholestasis and cytolysis) (see section 4.8). However, the protein binding is so low that no interactions with other compounds would be expected on the basis of this mechanism. The tables below provide general recommendations for dosing. Additional considerations for dosing are needed when treating patients with renal insufficiency (see further below). Date of first authorisation/renewal of the authorisation. The symptoms include frequent infections, high temperature and sore throat. Renal impairment results in higher plasma AUC and longer half-life for meropenem. Talk to your doctor, pharmacist or nurse before taking Meropenem. Hypersensitivity to the active substance or to any of the excipients listed in section 6.1. EUCAST clinical MIC breakpoints for meropenem (2015-01-01, v5), Haemophilus influenzae1,2 and Moraxella catarrhalis2, Gram-positive anaerobes except Clostridium difficile. Qualitative and quantitative composition a) Each vial of powder for solution for injection or infusion contains 570.78 mg meropenem trihydrate equivalent to 500mg anhydrous meropenem. The dose depends on the type of infection that you have, where the infection is in the body and how serious the infection is. These may be signs of a multi-organ sensitivity disorder known as DRESS syndrome. The solution should be shaken before use.